Doctor Discussion Guide

What should I ask my treatment team?

It is important to know who is on your KYMRIAH^® (tisagenlecleucel) treatment team and how to get in touch with them. Remember to ask for names, telephone numbers, email addresses, and any other contact information.

Here are some suggested questions to ask your medical team during each step of your KYMRIAH treatment process.

1. Initial Discussion

• How does my treatment history affect my eligibility for KYMRIAH?

• Can I receive KYMRIAH if I've already received a stem cell transplant?

• Can I receive a stem cell transplant if I've already received KYMRIAH?

• What if I have other health conditions?

• How will I feel throughout the treatment process?

• Where can I receive KYMRIAH therapy?

• How long will I need to stay near the treatment center?

• Will my insurance cover KYMRIAH therapy?

2. Collection

• How should I prepare for collection?

• How long will it take?

• What can I do during collection?

• Will there be any limitations or side effects afterward?

• How soon after collection will my KYMRIAH CAR-T cells be ready for infusion?

3. Preinfusion Lymphodepleting Chemotherapy

• How is this chemotherapy different from the chemotherapy I previously received?

• How long will it take?

• Will there be side effects?

• How far in advance of my infusion do I receive chemotherapy?

4. Infusion

• How should I prepare for infusion?

• What will infusion be like?

• How long will it take?

5. Side Effects and Monitoring

• What precautions do I need to take after treatment?

• What side effects should I expect after infusion?

• How will serious side effects be managed after therapy?

• How will I know KYMRIAH is working?

• What will be my monitoring plan after treatment?

• When do I need to check in with my treatment team?

• How long do I need to stay near my treatment center?

• After returning home, what kind of side effects require a hospital visit?

• How quickly can I get back to my daily routine?

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